American Dad! Season 6 Episode 1 (American Dad! s06e01) with title “100 A.D.” aired on Sunday, October 3rd 2010 at 09:30 pm via FOX Network.
Here is summary for American Dad! Season 6 Episode 1 :

Season 6 opener: Hayley elopes with her slacker-stoner boyfriend, Jeff, much to Stan and Francine’s dismay. So Stan offers a $50,000 reward to anyone who can stop the nuptials. Part 1 of 2.