Human Target Season 2 Episode 1 (Human Target s02e01) with title “Ilsa Pucci” aired on Friday, October 1st 2010 at 08:00 pm via FOX Network.
Here is summary for Human Target Season 2 Episode 1 :

In the Season 2 premiere, Chance and Guererro hatch a plan to rescue the kidnapped Winston. Meanwhile, a philanthropist (Indira Varma) fears her husband’s death may be followed by her own; and a young thief (Janet Montgomery) sees a mentor in Guererro.

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